ABSTRACT
ABSTRACT Objective: To develop and validate a new psychometric tool for assessing malocclusion-related quality of life among older Indian adolescents. Methods: Item generation involved analysis of existing validated tools, followed by development of new items using various qualitative steps. A draft item pool of 41 questions was initially generated and subjected to item reduction through sequential steps involving two clinical studies to ensure reliability and validity. 431 subjects aged between 15 to 18 years took part in the validation study. Principal component analysis with varimax rotation was performed to get a psychometric tool with good factorial structure and maximum variance. Results: Rotated component matrix resulted in a 20 item psychometric tool containing 4 domains with a total variance of 61.57%. Inter item, item total correlation and Cronbach α (α = 0.88) ensured good reliability. A positive correlation of the scale with global question ensured convergent validity. Independent t test showed statistically significant difference (p< 0.05) between mean score of IOTN-DHC and DAI with MRQoLQ, ensuring good construct validity. Conclusions: The newly developed psychometric tool is named as Malocclusion-Related Quality of Life Questionnaire (MRQoLQ) having 20 questions, including 2 socioeconomic items. The scale showed good reliability and initial validity, hence can be used among older adolescents with malocclusion to assess their malocclusion-related quality of life.
RESUMO Objetivo: desenvolver e validar uma nova ferramenta psicométrica para avaliar o impacto da má oclusão na qualidade de vida em pacientes indianos ao final da adolescência. Método: o delineamento do conjunto de itens desse questionário envolveu a análise de ferramentas existentes já validadas, seguida da criação de novos itens, usando vários passos qualitativos. Um conjunto provisório de itens, com 41 perguntas, foi inicialmente formulado e submetido à redução de itens por meio de passos sequenciais envolvendo dois estudos clínicos, para garantir sua validade e confiabilidade. Nesse estudo de validação, participaram 431 pacientes com idades entre 15 e 18 anos. Foi realizada uma análise do componente principal pelo método Varimax, para se obter uma ferramenta psicométrica com boa estrutura fatorial e variância máxima. Resultados: a matriz, após as rotações dos fatores, resultou em uma ferramenta psicométrica com 20 itens, contendo 4 domínios, com uma variância total de 61,57%. As correlações interitens e item-total e o alfa de Cronbach (α = 0,88) confirmaram uma boa confiabilidade. Uma correlação positiva da escala com a questão global assegurou validade convergente. O teste t independente demonstrou diferença estatisticamente significativa (p< 0,05) entre a pontuação média do IOTN-DHC e do DAI com o MRQoLQ, assegurando uma validade bem construída. Conclusões: essa nova ferramenta psicométrica desenvolvida, denominada Questionário "Impacto da Má Oclusão na Qualidade de Vida" (MRQoLQ, do inglês Malocclusion-Related Quality of Life Questionnaire), com 20 perguntas, incluindo 2 itens socioeconômicos, demonstrou boa confiabilidade e validade inicial. Assim, pode ser utilizado em pacientes no final da adolescência, para avaliar o impacto da má oclusão em sua qualidade de vida.
Subject(s)
Humans , Adolescent , Quality of Life , Malocclusion , Psychometrics , Surveys and Questionnaires , Reproducibility of ResultsABSTRACT
Background: Calcium phosphate cements (CPC) are a group of biomaterials possessing wide scope of use in various branches of medical science. These materials have been proposed to be highly biocompatible and osteoconductive. This study is based on a newly developed CPC formulation (Chitra-CPC) and is aimed at the evaluation of its biocompatibility through an Endodontic Usage Test in a porcine study model. Objective: To evaluate the periapical tissue reaction to Chitra-CPC when used as a root canal sealer/filler material in comparison with a resin sealer, AH Plus (Dentsply). Materials and Methods: The procedure was done on porcine animal model following the ISO 7405 criteria. The material was implanted intentionally into the periapical area of 36 teeth through a root canal procedure carried out in six animals which were divided equally among 1-month and 3-month time periods. Results were based on the histological evaluation of the autopsied specimens after the prescribed time periods. Results: Mild to moderate periapical tissue reaction was found in Chitra-CPC samples belonging to the 1-month time period, whereas majority of the 3-month CPC samples showed an absence of inflammation. Samples of AH Plus in 1-month period showed severe to moderate inflammation, whereas 3-month AH Plus samples had a mild to moderate inflammation. Conclusions: Chitra-CPC is a biocompatible material.